Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00931762
Details
2021-07-30
Interventional
2
[1 Refs]
35 
Panobinostat
Polycythemia Polycythemia Ve… Primary Myelofi… Thrombocytopeni… Post-Essential … Post-Polycythem…
-
-
NCT00473824
Details
2021-07-30
Interventional
27 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Hepatitis Hepatitis A Hepatitis C Evidence of Liv… Sequelae of Vir… Transplantation…
New sponsor's decision to pursue a redesigned clinical study
Early termination by sponsor due to data from the initial 7 patients of 36 planned for this study. Therefore, statistical analysis was not performed and no conclusion were reached regarding efficacy or drug safety.
NCT04764383
Details
2021-07-29
Interventional
20 
Histamine
Fatigue Multiple Sclero… Sclerosis
Withdrawn as more data drug analysis is recommended before the study.
-
NCT03033511
2016-003503-64
Details
2021-07-29
Interventional
3748 
BB 1101 Dexamethasone Dexamethasone a… Immunoconjugate… Rovalpituzumab …
Lung Neoplasms Small Cell Lung… Small Cell Lung…
Independent Data Monitoring Committee recommendation
-
NCT01812135
Details
2021-07-29
Interventional
20 
Vaccines
Virus Diseases Infection, Vira…
Based on the previous study results, inactivated EV71 vaccine with aluminum adjuvant was elected to be used for the efficacy Phase III study.
-
NCT01440062
Details
2021-07-29
Interventional
255 
Cholecalciferol Ergocalciferols Vitamin D Vitamins
Multiple Sclero… Sclerosis
-
-
NCT00860379
Details
2021-07-29
Interventional
414 
Selenium
Burns
Due to a shift in primary responsibilities, the PI was not longer able to enroll subjects.
-
NCT04906876
Details
2021-07-28
Interventional
20 
Docetaxel Gemcitabine
Hemangiosarcoma Histiocytoma, M… Leiomyosarcoma Liposarcoma Rhabdomyosarcom… Sarcoma Sarcoma, Synovi… Angiosarcoma Bone Sarcoma High Grade Sarc… Metastatic Sarc… Myxofibrosarcom… Soft Tissue Sar… Spindle Cell Sa… Synovial Sarcom… Undifferentiate…
IND withdrawn
-
NCT04136444
Details
2021-07-28
Interventional
112 
Padsevonil
Healthy Study P… Impaired Hepati…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures
-
NCT03486353
Details
2021-07-27
Interventional
20 
Azacitidine
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
Program terminated
-
NCT02930343
Details
2021-07-27
Interventional
3136 
Folic Acid Glucocorticoids Hydroxychloroqu… Leflunomide Methotrexate Prednisolone Sulfasalazine
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Due to time constraints, the study was halted prematurely
Early termination resulted in enrollment of 136 patients instead of 140 patients.
NCT04584034
Details
2021-07-23
Interventional
40 
Albuterol Bronchodilator …
Respiratory Sou… Wheezing
Premature ending of the study due to impossibility of obtaining a suitable placebo-inhaler
-
NCT04474210
Details
2021-07-23
Interventional
11 
JNJ-56136379
Renal Insuffici…
Strategic Decision
-
NCT03277352
Details
2021-07-22
Interventional
1/210 
Pembrolizumab
Neoplasms Advanced Malign… Metastatic Canc…
The study was terminated due to emergent data from another study and unrelated to safety.
-
NCT02476994
Details
2021-07-21
Interventional
41 
Soybean oil, ph…
Essential Fatty…
Based on feedback from FDA
-
NCT04370834
Details
2021-07-20
Interventional
21 
Immunoglobulin … Immunoglobulins
Acute Lung Inju… COVID-19 Laboratory Infe… Neoplasms Pneumonia Respiratory Dis… Respiratory Dis… Hematopoietic a… Malignant Solid… Pneumonitis Severe Acute Re… Symptomatic COV…
Other - Randomized data no longer support continuation
Early termination as randomized data did not support continuation.
NCT02579863
2015-002901-12
Details
2021-07-20
Interventional
3310 
Dexamethasone Lenalidomide Pembrolizumab
Multiple Myelom… Neoplasms, Plas…
The study was terminated early due to business reasons
The MK-3475-185 study was stopped/terminated early. Endpoint statistics may be biased due to the incomplete treatment and follow-up of participants after study termination
NCT04117607
Details
2021-07-16
Interventional
114 
Rezafungin
Mycoses Fungal Infectio…
Stopped due to the formation of injection site skin nodules.
-
NCT02439970
Details
2021-07-16
Interventional
35 
Brincidofovir Valganciclovir
Cytomegalovirus… Cytomegalovirus…
Study was terminated early due to results from another CMX001 study
No conclusions regarding safety or efficacy can be made from the limited data obtained in this study. Enrollment was suspended and all blinded study treatment was discontinued early January 2016.
NCT02439957
Details
2021-07-16
Interventional
36 
Brincidofovir Valganciclovir
Cytomegalovirus… Cytomegalovirus… Kidney Transpla…
Study terminated early due to results from another CMX001 study.
The study was terminated. Enrollment was suspended and all blinded study treatment was discontinued in early January 2016. No conclusions can be made from this study.