Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03909295
Details
2021-10-08
Interventional
352 
Sacubitril and … Valsartan
Heart Failure Heart Failure W…
This study was terminated early because the primary endpoint of PARAGON-HF was not met.
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NCT02647255
Details
2021-10-08
Interventional
2/310 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Acute Kidney In… Glomerulonephri… Glomerulonephri… Kidney Diseases Renal Insuffici… Acute Renal Ins… Rapidly Progres…
Due to the rarity and rapid progressive course of the disease, patients were less likely to participate in randomization.
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NCT02576977
2015-002509-13
Details
2021-10-08
Interventional
3251 
Dexamethasone Pembrolizumab Pomalidomide
Multiple Myelom… Neoplasms, Plas…
The study was terminated early due to business reasons
The MK-3475-183 study was stopped/terminated early. Endpoint statistics may be biased due to the incomplete treatment and follow-up of participants after study termination
NCT04252248
Details
2021-10-06
Interventional
13 
Decitabine
Head and Neck N… Anogenital Canc… Head and Neck C…
Organizational reasons
-
NCT04025177
Details
2021-10-06
Interventional
20 
Indomethacin
Ductus Arterios… Premature Birth Patent Ductus A…
Halted due to feasibility issues
-
NCT02298166
Details
2021-10-06
Interventional
39 
Crenolanib Cytarabine Mitoxantrone
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
The manufacturer Arog Pharmaceuticals Inc has terminated the Agreement Concerning the Support of an Investigator Initiated Trial this became valid on 2020/03/09
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NCT01468311
Details
2021-10-06
Interventional
1/26 
Daclizumab
Hodgkin Disease Lymphoma Hodgkin Lymphom…
Poor enrollment and ability to radioconjugate Daclizumab. Neither Center for Cancer Research (CCR) or Nuclear Medicine/Radiology wanted to do the facilities upgrade and hire personnel needed to radioconjugate the drug at the Clinical Center.
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NCT00615160
2005-002192-32
Details
2021-10-06
Interventional
1/29 
Dacarbazine Vatalanib
Melanoma
Substance was withdrawn from further development.
-
NCT04882163
2020-005333-32
Details
2021-10-05
Interventional
1/20 
Bendamustine Hy… Dexamethasone Gemcitabine Lenalidomide Polatuzumab ved… Rituximab
Lymphoma Lymphoma, B-Cel…
Business objectives have changed
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NCT01496612
Details
2021-10-05
Interventional
29 
Buspirone
Anxiety Disorde… Epilepsies, Par… Epilepsy Seizures Anxiety Disorde… Depression Partial Epileps…
-
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NCT04325698
Details
2021-10-04
Interventional
38 
Bevacizumab Carboplatin Paclitaxel
Carcinoma, Non-… Advanced Non-sq…
The study was terminated as part of the decision by Pfizer to halt its biosimilars programs in China.
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NCT03560011
2017-000826-36
Details
2021-10-04
Interventional
2/3-
Antibodies Immunoglobulins Immunoglobulins…
Nephrosis Nephrotic Syndr… Syndrome Steroid-Depende…
Decision of Data Safety Monitoring Board
-
NCT01549886
Details
2021-10-04
Interventional
25 
Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H… Non-Hodgkin's L…
Due to business reasons.
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NCT04614298
Details
2021-09-30
Interventional
40 
Brodalumab
Psoriasis Moderate to Sev…
Due to the reconsideration of KHK4827's business in China, it. was decided to withdraw this clinical trial prior to enrollment of first participant.
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NCT01170650
Details
2021-09-30
Interventional
3441 
Doxorubicin Liposomal doxor…
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
DSMB decision
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NCT03607955
Details
2021-09-29
Interventional
10 
Carboplatin Paclitaxel
Carcinoma, Ovar… Fallopian Tube … Epithelial Ovar… Fallopian Tube … Primary Periton…
Trial may move forward as an NCI-sponsored trial and not an investigator initiated trial.
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NCT03260972
Details
2021-09-29
Interventional
30 
Chloroprocaine
Cesarean Sectio… Pain
Withdrawn by IRB
-
NCT02833766
Details
2021-09-29
Interventional
248 
Doxorubicin
Breast Neoplasm… Breast Cancer
the trial was prematurely terminated as per SAKK board decision from 14th of November 2020. The trial is to be terminated after primary endpoint is reached.
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NCT02272868
Details
2021-09-29
Interventional
1/27 
Omeprazole Polyethylene gl… Rifaximin
Crohn Disease Crohn's Disease
-
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NCT03224182
Details
2021-09-28
Interventional
3118 
Apaziquone
Urinary Bladder… Bladder Cancer
Suspended development
The study was terminated as per Sponsor's decision.