Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04900766
Details
2024-03-07
Interventional
131 
Mitoxantrone
Sarcoma Unresectable or…
The sponsor has adjusted its R&D strategy.
-
NCT04718402
Details
2024-03-07
Interventional
121 
Mitoxantrone
Carcinoma Stomach Neoplas… Advanced Gastri…
The sponsor has adjusted its R&D strategy.
-
NCT04718376
Details
2024-03-07
Interventional
156 
Mitoxantrone
Carcinoma, Ovar… Ovarian Neoplas… Platinum-resist…
The sponsor has adjusted its R&D strategy.
-
NCT04548700
Details
2024-03-07
Interventional
138 
Cyclophosphamid… Mitoxantrone Prednisone Vincristine
Lymphoma, T-Cel… Peripheral T Ce… Treatment-naïv…
The sponsor has adjusted its R&D strategy.
-
NCT04509466
Details
2024-03-07
Interventional
1/241 
Asparaginase Mitoxantrone Pegaspargase
Lymphoma, Extra… Extranodal NK/T…
The sponsor has adjusted its R&D strategy.
-
NCT03973333
Details
2024-03-07
Interventional
1/275 
Atezolizumab
Select Advanced…
The Sponsor terminated the study and there is no further enrollment. Endpoints will not be assessed for this trial.
-
NCT02498977
2014-004557-14
Details
2024-03-07
Interventional
4116 
Azathioprine Cyclosporine Cyclosporins Mycophenolic Ac… Tacrolimus
Transplantation…
Primary endpoint not reached.
-
NCT05807126
Details
2024-03-06
Interventional
1-
Magrolimab Olaparib Poly(ADP-ribose…
Prostatic Neopl… Anatomic Stage … Castration-Resi… Stage IVB Prost…
Added per CS0161016, see memo uploaded to trial related documents.
-
NCT05536882
Details
2024-03-06
Interventional
30 
Adapalene Benzoyl Peroxid…
Molluscum Conta…
The original PI left the institution prior to final IRB approval and the remaining study team did not have the resources to continue.
-
NCT05005507
2021-002450-81
Details
2024-03-06
Interventional
21 
Peginterferon a… Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Herpesviridae I… Virus Diseases
A strategic decision was made to not further execute the study. This decision was not based on a safety concern.
Only 1 participant was enrolled in the study in Arm 1. Participants were also planned to be enrolled in Arms 2 and 3 but were not enrolled as the study terminated prematurely based on a strategic decision and not for safety reasons.
NCT04609046
Details
2024-03-06
Interventional
1-
Antibodies Antibodies, Mon… Antineoplastic … Immunoglobulins Lenalidomide Methotrexate Nivolumab Rituximab
Lymphoma Lymphoma, Large… Primary Diffuse…
Other - Awaiting amendment approval
-
NCT04340843
Details
2024-03-06
Interventional
2-
Azacitidine Belinostat Decitabine Decitabine and … Guadecitabine
Chondrosarcoma Locally Advance… Metastatic Prim… Unresectable Pr…
Other - Completed stage 1 accrual
-
NCT05915286
Details
2024-03-05
Interventional
4-
Chlorthalidone Furosemide
Kidney Failure,… End Stage Renal…
Personnel/staffing issues.
-
NCT05845008
Details
2024-03-05
Interventional
30 
Acetaminophen Naproxen
Orthodontic Pai…
The study is no longer required due to change in development program strategy.
-
NCT05564416
Details
2024-03-05
Interventional
20 
Antibodies, Mon… Atezolizumab
Carcinoma Carcinoma, Tran… Urinary Bladder… Bladder Carcino… Bladder Urothel… Muscle Invasive… Renal Pelvis an… Stage II Bladde… Stage III Bladd… Stage IVA Bladd… Urothelial Carc…
Feasibility issues per Complete Sheet
-
NCT05552157
Details
2024-03-05
Interventional
2/3-
Antibodies, Mon…
Alzheimer Disea… Dementia Alzheimers Dise… Alzheimers Dise…
Roche announced a decision to discontinue most of the company's global trials of gantenerumab. The DIAN-TU has paused the DIAN-TU-002 Primary Prevention Trial related to gantenerumab while considering other potential options for this platform trial.
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NCT05223673
2021-003151-41
Details
2024-03-05
Interventional
37 
Trifluridine
Colorectal Neop… Metastatic Colo…
Sponsor decided to discontinue the study during the Lead-In part and the Phase III part was not started due to strategic reasons.
-
NCT04816214
2020-003677-21
Details
2024-03-05
Interventional
36 
Carboplatin Osimertinib Pemetrexed
Carcinoma, Non-…
Novartis decided to terminate the study based on a business consideration and not related with any safety concerns. Randomized part was not initiated
-
NCT03871348
2017-004766-94
Details
2024-03-05
Interventional
177 
Cemiplimab
Neoplasm Metast… Metastatic Neop…
Sponsor terminated the study for non-safety reasons
-
NCT03341962
2017-003703-22
Details
2024-03-05
Interventional
2263 
Calcium
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
Considering the efficacy results of the induction phase (allowed use of corticosteroids as concomitant medication) in the study population and since IMU-838 did not show superiority over placebo, the OLE was prematurely closed by the sponsor.
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