Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03736967
2018-001543-30
Details
2021-11-01
Interventional
2206 
Antibodies, Mon…
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
Lack of efficacy
The decision was made by the sponsor to terminate the study on 12 Feb 2020 due to lack of efficacy. Study enrollment was not complete at that time, therefore planned sample sizes were not met. Participants discontinued study drug and transitioned into the post-treatment follow-up period. As a result of the decision to terminate the study, all statistical analyses were descriptive and no hypothesis testing was performed.
NCT03593109
Details
2021-11-01
Interventional
11 
Immunomodulatin…
Lymphoma Lymphoma, B-Cel…
Suitable patients were not recruited
-
NCT02555293
Details
2021-11-01
Interventional
2-
Rifaximin
Liver Diseases Major Liver Res… Malignant Liver…
Prematurely terminated due to organisational reasons
-
NCT04540848
Details
2021-10-29
Interventional
40 
Bupivacaine
Pain, Postopera… Post Operative …
Lack of ability to communicate with the study population
-
NCT04531592
Details
2021-10-29
Interventional
20 
Valproic Acid
Acute Kidney In… Ischemia Reperfusion Inj… Wounds and Inju… Ischemia Reperf…
Study terminated by the Sponsor
-
NCT04531579
Details
2021-10-29
Interventional
20 
Pharmaceutical … Valproic Acid
Acute Kidney In… Ischemia Reperfusion Inj… Wounds and Inju… Ischemia Reperf…
Study terminated by the Sponsor.
-
NCT03481842
Details
2021-10-29
Interventional
1/20 
Afatinib Axitinib
Endometriosis Endometriosis E… Endometriosis O… Endometriosis, …
Change in study design and sponsor
-
NCT02792192
Details
2021-10-28
Interventional
1/224 
Atezolizumab
Non-Muscle Inva… Urinary Bladder… Bladder Cancer
The study was terminated early as the study had met its goals of providing preliminary safety and efficacy information for atezolizumab monotherapy alone and in combination with BCG in NMIBC.
Participants were enrolled only in Cohort 1 of this study. The Sponsor decided not to enroll participants in Cohorts 2 and 3 after the enrollment of 24 patients in Cohort 1 (BCG-unresponsive cohort), as the study had met its goals of providing preliminary safety and efficacy information for atezolizumab monotherapy alone and in combination with BCG in NMIBC.
NCT01035658
Details
2021-10-28
Interventional
1/222 
Doxorubicin Liposomal doxor…
Adenocarcinoma Fallopian Tube … Hypersensitivit… Fallopian Tube … Ovarian Cancer Peritoneal Carc…
Based on analyses in Phase I, the study did not advance to Phase II.
Per protocol, study did not proceed to phase II based on analyses from phase I. Therefore, Phase II outcomes (all outcomes other than determination of the MTD) were not evaluated and will not be posted.
NCT04381988
Details
2021-10-27
Interventional
24 
Hydroxychloroqu…
COVID-19 Cancer
The study was terminated based results of other studies and use of the new vaccine.
-
NCT03504917
Details
2021-10-27
Interventional
3322 
Balovaptan
Autism Spectrum… Autistic Disord… Child Developme…
A futility analysis assessed that the study is highly unlikely to meet the pre-defined primary objective of the study. No new safety concerns were identified.
-
NCT03422094
Details
2021-10-27
Interventional
13 
Ipilimumab Nivolumab Poly ICLC
Glioblastoma
Manufacturer changed focus to cell therapy
-
NCT02563561
Details
2021-10-27
Interventional
362 
Apaziquone
Urinary Bladder… Bladder Cancer
-
The study was terminated as per Sponsor's decision.
NCT01960023
Details
2021-10-27
Interventional
1/20 
Cetuximab Neratinib
Colorectal Neop… Colorectal Canc…
This registry was planned to report on the Phase II portion of the study. NSABP decided not to proceed with the Phase II portion of the study.
-
NCT03685344
2018-002670-43
Details
2021-10-26
Interventional
113 
Antibodies, Mon… Durvalumab Loncastuximab t…
Lymphoma Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Large… Lymphoma, Mantl… Diffuse Large B… Follicular Lymp… Mantle Cell Lym…
In a limited number of patients, no additional activity was evident for the combination vs. loncastuximab tesirine monotherapy.
-
NCT03581084
Details
2021-10-26
Interventional
41 
Acetylcysteine N-monoacetylcys…
Asthma
The study was redesigned to be conducted in an outpatient setting.
-
NCT02687451
Details
2021-10-26
Interventional
328 
Oxymorphone
Acute Pain Pain, Postopera… Post-Operative …
Released from PMR
-
NCT04958967
Details
2021-10-25
Interventional
10 
Aflutinib
NSCLC
The protocol need to review
-
NCT03467217
Details
2021-10-21
Interventional
283 
Losartan
Fatty Liver Liver Diseases Non-alcoholic F… NAFLD - Nonalco…
Trial stopped for futility
-
NCT03469050
2017-002708-28
Details
2021-10-20
Interventional
2/3193 
Rifaximin
Diverticulitis
Sponsor's decision
-