Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03618823
Details
2021-11-10
Interventional
1/2268 
Acetaminophen Ibuprofen Oxycodone
Agnosia Adenotonsillect… Opioid Use Post-operative …
Early termination due to COVID-19 cases and cancelled surgeries.
Early termination due to COVID-19 cases and cancelled surgeries.
NCT04414631
Details
2021-11-09
Interventional
280 
Complement C1 I…
COVID-19 Communicable Di… Coronavirus Inf… Infections
Aim to enroll 120 patients deemed not sufficient to show a difference in the primary outcome measure. Standard of care treatment recently changed in Switzerland adding further heterogeneity to trial population when including future participants.
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NCT03927911
Details
2021-11-09
Interventional
465 
Bupivacaine
Pain, Postopera… Postoperative P…
Due to protocol feasibility given the rapid evolution of medical practice for spinal procedure. Data from approximately 65 FUSION study subjects will be analyzed with the intent to create either a future study or registry for this patient population.
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NCT03379259
2018-000265-37
Details
2021-11-09
Interventional
1/239 
Tislelizumab
Neoplasms Advanced Solid …
Study Was Terminated Early
Phase 2A of the study was not initiated nor conducted since BGB-A333 as a monotherapy treatment beyond the completion of dose escalation in Phase 1A was not pursued.
NCT03184558
2016-003608-30
Details
2021-11-09
Interventional
229 
Pembrolizumab
Breast Neoplasm… Inflammatory Br… Triple Negative… Inflammatory Br… Triple Negative…
Based on planned futility assessment
None of the participants achieved CR or PR. As there were no responses, the study was terminated. It was planned to terminate the trial in favor of the null hypothesis of futility when 5 or fewer responses were observed in 28 participants.
NCT04422210
2019-004487-22
Details
2021-11-08
Interventional
12 
Atezolizumab Carboplatin Etoposide Venetoclax
Lung Neoplasms Small Cell Lung… Small Cell Lung…
Decision to discontinue the study based on broader development and strategic prioritisation. The Sponsor concludes there is no benefit-risk impact on the GO41864 study.
The study was terminated by the Sponsor. Only 2 participants were enrolled in this study. Based on the low enrolment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
NCT04298918
2019-004200-35
Details
2021-11-08
Interventional
1/21 
Ado-Trastuzumab… Maytansine Trastuzumab Venetoclax
Breast Neoplasm… Breast Cancer
Decision to discontinue the study based on broader development and strategic prioritisation. The Sponsor concludes there is no benefit-risk impact on the CO41863 study.
The study was terminated by the Sponsor. Only 1 participant was enrolled in this study. Based on the low enrolment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
NCT03705273
Details
2021-11-08
Interventional
440 
BB 1101 Dexamethasone Dexamethasone a…
Asthma Croup
Dr. Arnold assisted in designing and initiating study for a pharmacology PhD candidate. The candidate left the institution and study enrollment was terminated.
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NCT00210119
Details
2021-11-08
Interventional
219 
Imatinib Mesyla…
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myeloid Leukemi…
-
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NCT02212574
Details
2021-11-05
Interventional
16 
Cyclophosphamid… Lomustine Vincristine
Medulloblastoma
Participant relapses led to abrupt stop of study.
Two of the participants relapsed not long into the study and the Data and Safety Management Committee (DSMC) recommended early closure of the study.
NCT00270257
Details
2021-11-05
Interventional
31251 
Buprenorphine Buprenorphine, … Naloxone
Acquired Immuno… Communicable Di… HIV Infections Infections Opioid-Related …
DSMB halted the study due to futility as a result of lower than anticipated HIV incidence rates
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NCT02160730
Details
2021-11-04
Interventional
24 
Roscovitine
ACTH-Secreting … Pituitary ACTH … Cushings Diseas…
NIH grant ended.
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NCT00000961
Details
2021-11-04
Interventional
2-
Immune Sera Zidovudine
Acquired Immuno… HIV Infections Infections
-
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NCT04434001
Details
2021-11-03
Interventional
240 
Thrombin
Acute Lung Inju… Heart Defects, … Heart Diseases Lung Injury Transfusion Rea… Transfusion-Rel… Bleeding Cardiac Defect Congenital Hear… Fibrinogenopeni… Surgery--Compli… Transfusion-Ass…
The study encountered unexpected difficulties in enrolling patients due to requirements for the Informed Consent. 60% of our patients comes from abroad with only one accompanying parent. The rules of our EC require both parents to sign the consent.
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NCT03769688
Details
2021-11-03
Interventional
10 
Metronidazole
Vaginal Disease… Vaginosis, Bact… Bacterial Vagin…
Replaced with different study at another site.
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NCT02571530
Details
2021-11-03
Interventional
12 
Trastuzumab
Neoplasm Metast…
Low enrollment
-
NCT02438995
Details
2021-11-03
Interventional
111 
Cetuximab
Carcinoma Carcinoma, Squa… Squamous Cell C… Carcinoma, Squa…
Low enrollment
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NCT00000730
Details
2021-11-03
Interventional
3-
Leucovorin Levoleucovorin Methylprednisol… Pentamidine Sulfamethoxazol… Trimethoprim Trimethoprim, S… Trimetrexate
Pneumonia Pneumonia, Pneu… HIV Infections Pneumonia, Pneu…
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NCT04794205
Details
2021-11-02
Interventional
1/20 
Caryophyllene
Beta-Caryophyll…
Delayed project onset; PI determined pilot data could be collected at a later date.
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NCT03645603
2015-002114-80
Details
2021-11-02
Interventional
2
[1 Refs]
45 
Dexmedetomidine
Substance Withd… Withdrawal Synd…
futility reasons
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