Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02422368
Details
2022-01-10
Interventional
2/30 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Eye Diseases Graves Ophthalm… Thyroid Disease… Thyroid Eye Dis…
Do not access to the drug
-
NCT04338828
Details
2022-01-06
Interventional
247 
Nitric Oxide
COVID-19 Infections COVID19
Absence of patients meeting criteria following initial COVID surge. DMSB recommended analysis of results to date and early closure.
-
NCT03386214
Details
2022-01-06
Interventional
18 
Pevonedistat
Primary Myelofi… Myelofibroses
Sponsor stopped development of pevonedistat
-
NCT00637832
2007-000222-51
Details
2022-01-06
Interventional
21 
Cyclophosphamid… Doxorubicin Liposomal doxor… Prednisolone Rituximab Vincristine
Lymphoma Lymphoma, Folli…
no information
-
NCT04353271
Details
2022-01-03
Interventional
2/33 
Hydroxychloroqu…
COVID-19 Coronavirus Inf… Corona Virus In… Covid 19
FDA recommendations to not use outside of the hospital setting or in a clinical trial due to the risk of cardiac arrhythmias
-
NCT01150890
2010-019544-39
Details
2022-01-03
Interventional
2130 
Brodalumab
Crohn Disease Crohn's Disease
The study was terminated early based on an imbalance in worsening Crohn's disease in active treatment groups
-
NCT02228382
2013-003250-25
Details
2021-12-30
Interventional
4163 
Bosutinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Philadelphia Ch… Previously Trea…
-
-
NCT03370120
2017-003241-26
Details
2021-12-29
Interventional
2406 
Padsevonil
Drug Resistant … Epilepsy Seizures Drug-Resistant … Focal-Onset Sei…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizure
-
NCT01380028
2009-015524-28
Details
2021-12-28
Interventional
3162 
Prednisone
Hematoma Hematoma, Subdu… Hematoma, Subdu… Hematoma, Subdu… Chronic Intracr…
successfull Interim Analysis
-
NCT01199302
2010-020881-53
Details
2021-12-28
Interventional
267 
Brodalumab
Crohn Disease Crohn's Disease
The study was terminated early based on an imbalance in worsening Crohn's disease in active treatment groups.
-
NCT01123707
2010-018860-17
Details
2021-12-22
Interventional
3173 
Aripiprazole Escitalopram
Depression Depressive Diso… Depressive Diso… Major Depressiv…
The study was terminated early due to Sponsor decision; no safety issues.
The study was terminated early due to Sponsor decision; no safety issues.
NCT00372073
Details
2021-12-22
Interventional
2187 
Roscovitine
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
-
-
NCT01111565
2010-018859-97
Details
2021-12-21
Interventional
3137 
Aripiprazole Escitalopram
Depression Depressive Diso… Depressive Diso… Major Depressiv…
The study was terminated early due to Sponsor decision, closure of this combination therapy program is unrelated to any safety issues, no signals of concern.
The study was terminated early due to Sponsor decision, closure of this combination therapy program is unrelated to any safety issues, no signals of concern.
NCT03050814
Details
2021-12-20
Interventional
230 
Avelumab Bevacizumab Capecitabine Fluorouracil Leucovorin Oxaliplatin
Colorectal Neop… Colorectal Aden… Colorectal Canc… Colorectal Carc… Colorectal Tumo…
Terminated after an unplanned interim efficacy analysis.
-
NCT04648826
Details
2021-12-17
Interventional
1/20 
Azacitidine
Carcinoma, Rena… Lung Neoplasms Neoplasm Metast… Neoplasms Neoplasms, Germ… Sarcoma Epithelial Mali… Germ Cell Tumor… Melanomas Pulmonary Metas… Sarcomas
Due to notification from EMD Serono, for Bintrafusp alfa (M7824) regarding an observed increase in the frequently of early progression and death.
-
NCT03654729
Details
2021-12-17
Interventional
3291 
Edetic Acid Pyridoxal Phosp…
Colorectal Neop… Peripheral Nerv… Chemotherapy-in… Colorectal Canc…
On 23 January 2020, the Sponsor announced that the United States (US) Food and Drug Administration (FDA) had issued a clinical hold in the US of the POLAR program.
-
NCT00983437
Details
2021-12-17
Interventional
349 
Modafinil
Brain Injuries Brain Injuries,… Sleepiness Wounds and Inju… Traumatic Brain…
Study has been stopped by sponsor decision
The sponsor's decision to terminate the study early resulted in the small number of study participants, and related limitations to the interpretation of the study results.
NCT01510184
Details
2021-12-16
Interventional
379 
Antibodies, Mon… Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Large… Diffuse Large B… Follicle Center…
-
The study was terminated early due to a sponsor business decision.
NCT04345861
Details
2021-12-15
Interventional
2/37 
Azithromycin Hydroxychloroqu…
COVID-19 Coronavirus Inf… Pneumonia Pneumonia, Vira… Coronavirus Inf…
halted prematurely.
-
NCT03564145
Details
2021-12-15
Interventional
3547 
Benzoyl Peroxid…
Rosacea Papulopustular …
Per protocol, the Sponsor could terminate the study once 300 participants completed a total of 28 weeks of treatment and 100 participants completed a total of 52 weeks.
-