Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04377620
Details
2022-01-19
Interventional
3211 
Janus Kinase In…
COVID-19
Study terminated by sponsor
-
NCT03255083
Details
2022-01-19
Interventional
113 
Osimertinib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
This study was terminated based on a business decision by the Sponsor.
This study was terminated based on a business decision by the Sponsor.
NCT04005209
Details
2022-01-14
Interventional
40 
Ketamine
Acute Pain Anemia, Sickle … Anemia; Sickle-…
Decided not to open study
-
NCT02817347
Details
2022-01-13
Interventional
1/2135 
BB 1101 Dexamethasone Dexamethasone a… Piperacillin Tazobactam
Otitis Otitis Media Otorrhea
Sponsor's decision for the Drug Development.
-
NCT02567578
Details
2022-01-13
Interventional
212 
YH12852
Dyspepsia Functional Dysp…
Technology transfer
-
NCT04125745
Details
2022-01-12
Interventional
21 
CXA-10
Familial Primar… Hypertension Pulmonary Arter…
negative study outcome from Complexa's multicenter clinical trial; no safety concerns
The clinical trial was terminated early due to lack of efficacy based on the negative study outcome from the drug company's multicenter clinical trial. Early termination leading to small numbers of subjects analyzed.
NCT01509339
Details
2022-01-12
Interventional
10 
Vancomycin
Cystic Fibrosis Fibrosis Respiratory Asp… Methicillin-res…
Lab unable to measure vancomycin levels in Sputum
-
NCT00321100
Details
2022-01-12
Interventional
2
[1 Refs]
23 
Bevacizumab Capecitabine Cetuximab Oxaliplatin
Colorectal Neop…
Enrollment closed 10/15/2008 based on data about KRAS.
-
NCT04653389
Details
2022-01-11
Interventional
210 
Immunomodulatin…
Carcinoma Carcinoma, Hepa… Hepatocellular …
The treatment efficacy was not satisfactory.
-
NCT04296942
Details
2022-01-11
Interventional
11 
Ado-Trastuzumab… Entinostat Maytansine Trastuzumab
Breast Neoplasm… Triple Negative… Breast Cancer HER2+ Breast Ca… Hormone Recepto… Metastatic Brea… Triple Negative…
One participant was accrued, and the study was stopped due to new safety data from the company for M7824 and slow accrual.
-
NCT04278872
Details
2022-01-11
Interventional
213 
SJX-653
Hot Flashes
The study was terminated early as the goal of determining a safe and efficacious dose for further development for the treatment of VMS was not met
-
NCT03269409
Details
2022-01-11
Interventional
18 
Coal Tar
Osteonecrosis
Logistical delays from device manufacturer due to COVID
-
NCT03168438
Details
2022-01-11
Interventional
16 
Cyclophosphamid… Fludarabine Pembrolizumab
Multiple Myelom… Neoplasms, Plas… Neoplasms
The study was terminated following an internal review of the company's research and development portfolio
-
NCT02901483
Details
2022-01-11
Interventional
1/212 
Cisplatin
Head and Neck N… Squamous Cell C… Head and Neck S…
bussiness reason
-
NCT02874651
Details
2022-01-11
Interventional
225 
Apatinib
Carcinoma Epstein-Barr Vi… Nasopharyngeal … Nasopharyngeal …
Unacceptable toxicity (nasopharynx necrosis and massive hemorrhage)
-
NCT02465593
Details
2022-01-11
Interventional
1/2
[1 Refs]
32 
Capecitabine Fluorouracil
Rectal Neoplasm… Rectal Cancer
-
-
NCT02079948
Details
2022-01-11
Interventional
20 
Folic Acid Methotrexate Vitamin B Compl…
Inflammation Aging
Potential participants had concerns about taking the study drug (methotrexate).
-
NCT04931667
Details
2022-01-10
Interventional
373 
Lorecivivint
Osteoarthritis Osteoarthritis,… Osteoarthritis …
Study was terminated due to business reasons by Sponsor.
-
NCT04044781
Details
2022-01-10
Interventional
10 
BPN14770
To Determine Br…
Change in Research Direction
-
NCT03539601
2018-001043-31
Details
2022-01-10
Interventional
4237 
Hydrocortisone Hydrocortisone-… Pimecrolimus
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
This decision was made for business reasons only and is not related to any safety concerns regarding crisaborole.
Study was terminated early by sponsor. Decision was not due to safety/efficacy concerns, but was related to business, portfolio reprioritization. Sub-study planned as per Amendment 3 was not initiated, as sub study site setup didn't complete prior to study termination.