Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02668822
2015-004326-34
Details
2022-02-04
Interventional
318 
Ibuprofen
Dysmenorrhea
Study terminated by Sponsor as a result of a business decision to discontinue the development program for MK-8342B for reasons unrelated to safety or efficacy.
-
NCT02668783
2015-004325-14
Details
2022-02-04
Interventional
325 
Estradiol Estradiol 17 be… Estradiol 3-ben… Etonogestrel Ibuprofen Polyestradiol p…
Dysmenorrhea Moderate to Sev…
Study terminated by Sponsor as a result of a business decision to discontinue the development program for MK-8342B for reasons unrelated to safety or efficacy.
-
NCT02616146
2014-002208-26
Details
2022-02-04
Interventional
32016 
Estradiol Estradiol 17 be… Estradiol 3-ben… Ethinyl Estradi… Ethinyl estradi… Etonogestrel Levonorgestrel Polyestradiol p…
Contraception
Study terminated by Sponsor as a result of a business decision to discontinue the development program for MK-8342B for reasons unrelated to safety or efficacy.
Because the trial was terminated early, participant diary data used for efficacy analysis and bleeding analysis were not verified. These results should be interpreted with caution. No hypothesis testing was performed.
NCT00944216
Details
2022-02-04
Interventional
41 
Emollients
Abnormalities, … Darier Disease Keratosis Keratosis, Acti… Keratosis Pilar…
terminated due to administrative reasons.
-
NCT00651807
Details
2022-02-04
Interventional
216 
Etonogestrel
Hyperplasia Prostatic Hyper… Benign Prostati…
Business Reasons
-
NCT04287179
2019-004234-42
Details
2022-02-03
Interventional
30 
Semaglutide
Diabetes Mellit… Diabetes Mellit…
COVID19 impact on this trial was evaluated and a delay of at least 6-9 months was expected. In parallel, the development of a new type of pen injector, which was an important part of the trial, was ceased and thus this trial was cancelled.
-
NCT01656434
Details
2022-02-03
Interventional
33173 
Ethinyl Estradi… Ferrous fumarat…
Contraception
Business reasons
-
NCT00697255
2006-000705-30
Details
2022-02-03
Interventional
28 
Chorionic Gonad… Follicle Stimul… Hormones
Infertility Ovulation Induc…
-
-
NCT02236572
Details
2022-02-01
Interventional
217 
Everolimus
Breast Neoplasm… Breast Cancer
Phase 2 of recruitment was contingent on 5 of 15 patients responding, which did not occur.
-
NCT05178654
Details
2022-01-31
Interventional
10 
Nirmatrelvir
Healthy Partici…
Based on various healthy authorities feedback on PAXLOVID submission, this study is no longer required.
-
NCT03206463
Details
2022-01-31
Interventional
12 
Dronabinol
Bipolar Disorde… Delta-9-Tetrahy… Healthy Control…
Feasibility pilot was completed
-
NCT02335060
Details
2022-01-31
Interventional
15 
Acetylcysteine Dronabinol N-monoacetylcys…
Healthy
Feasibility pilot was completed
-
NCT03665129
Details
2022-01-27
Interventional
173 
Avdoralimab Durvalumab
Neoplasms Advanced Solid …
early termination
-
NCT00792831
2006-005465-19
Details
2022-01-27
Interventional
23 
Givinostat hydr…
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Protocol needs complete restructuring in order to make it feasible and to complete the enrollment of 23 patients.
-
NCT00496431
2007-000049-36
Details
2022-01-27
Interventional
1/219 
Givinostat hydr… Histone Deacety…
Hodgkin Disease Lymphoma Hodgkin's Lymph…
Study accrual was stopped earlier than planned by the Sponsor for 2 main reasons: very slow recruitment rate; lower than estimated efficacy of the drug when delivered as single agent.
-
NCT02933944
Details
2022-01-26
Interventional
16 
Pembrolizumab
Colorectal Neop… Rectal Cancer
Changing priorities
-
NCT05167370
Details
2022-01-25
Interventional
22 
Amifostine
Brain Neoplasms Neoplasms Brain Tumors Solid Tumors
The study was terminated as recommended by the DSMB due to inability to meet enrollment goals within the time frame allotted (target of 25 patients over 5 years).
-
NCT03447262
2017-004134-29
Details
2022-01-25
Interventional
3484 
Ivacaftor VX-659
Cystic Fibrosis Fibrosis
At Sponsor's Discretion
-
NCT04344444
Details
2022-01-21
Interventional
322 
Azithromycin Hydroxychloroqu…
COVID-19
Lack of efficacy data from other studies
-
NCT03207815
2017-001485-17
Details
2022-01-21
Interventional
274 
Prednisone
Uveitis Noninfectious U…
Development program terminated
Study was terminated early due to termination of the development program. Due to early termination and small sample size, pharmacokinetic (PK) analysis was not performed for this study.