Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04160195
Details
2022-02-15
Interventional
12 
Cyclophosphamid… Fludarabine
Hodgkin Disease Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H… B-Cell Chronic … Chronic Lymphoc… Lymphoma, Non-h…
The original principal investigator left the National Institutes of Health (NCI) and the decision was made to close the study to enrollment.
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NCT00449111
Details
2022-02-15
Interventional
311 
Losartan
Essential Hyper… Hypertension
-
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NCT04501211
Details
2022-02-14
Interventional
20 
Granisetron
Gastroparesis
Abandoned due to limited resources
-
NCT02678143
Details
2022-02-14
Interventional
11 
Alemtuzumab Cyclophosphamid… Fludarabine Mycophenolic Ac… Sirolimus
Anemia, Sickle … Sickle Cell Dis…
Closed early due to competing studies
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NCT00540839
Details
2022-02-14
Interventional
30 
Fluticasone Montelukast Xhance
Asthma Asthma, Bronchi…
Based on input from regulatory agencies, it is not necessary to conduct this study. An ongoing study was sufficient for regulatory purposes.
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NCT02348359
Details
2022-02-11
Interventional
2157 
Aflibercept Ranibizumab
Eye Diseases Macular Degener… Retinal Degener… Retinal Disease… AMD Age-Related Mac… Exudative Age-r… Macular Degener…
Interim analysis found study had achieved primary objective
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NCT05042934
Details
2022-02-10
Interventional
1/20 
Camptothecin Irinotecan
Sarcoma Sarcoma, Ewing Metastatic Ewin… Recurrent Ewing…
PI stated trial no longer fits the framework & portfolio of work that is prioritized by the department. PI will not have the anticipated accrual in PI view to complete the study. Given that, PI request this protocol be closed prior to its activation.
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NCT04608266
Details
2022-02-10
Interventional
370 
Camostat
COVID-19 Covid19
Scientific committee decision due SARS-CoV2 pandemic evolution with a decrease in inclusions and widespread distribution of vaccines
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NCT04928950
Details
2022-02-09
Interventional
20 
Charcoal
Lung Neoplasms Lung Cancer
Because of logistic challenges and lack of product among other factors, we decided to completely withdrawn this study.
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NCT02895373
Details
2022-02-09
Interventional
250 
Alprostadil
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Extracorporeal … Respiratory Dis…
After completion of pilot study (n=50) no effect on primary outcome and limited feasibility of recruitment and study procedures
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NCT00447603
Details
2022-02-09
Interventional
340 
Hydrochlorothia… Losartan
Hypertension
Achieving site readiness and enrolling the trial within a reasonable time
The study was discontinued early (during screening) due to limited availability of sites and readiness of sites to enroll participants within the predefined time.
NCT05008510
Details
2022-02-08
Interventional
20 
Camptothecin Immunoconjugate… Sacituzumab gov…
Breast Neoplasm… Triple Negative… Metastatic Trip…
Decided to halt and will potentially reopen in the future.
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NCT04119830
Details
2022-02-08
Interventional
20 
Pembrolizumab poly(I).poly(c1…
Adenocarcinoma Colorectal Neop… Metastatic Colo… Microsatellite … Mismatch Repair… Refractory Colo… Stage III Color… Stage IIIA Colo… Stage IIIB Colo… Stage IIIC Colo… Stage IV Colore… Stage IVA Color… Stage IVB Color… Stage IVC Color… Unresectable Co…
implementation issues
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NCT03912350
Details
2022-02-08
Interventional
10 
Balovaptan
Autism Spectrum…
The study is on hold due to stopping of the Autism Spectrum Disorder program with balovatpan, the study drug.
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NCT02354547
Details
2022-02-08
Interventional
1-
Cyclophosphamid… Topotecan
Neoplasm
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NCT03099486
Details
2022-02-07
Interventional
22 
Leucovorin
Colorectal Neop… Colorectal Canc…
Administrative change
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NCT01336530
2009-014441-93
Details
2022-02-07
Interventional
340 
Aluminum Hydrox… Antacids Magnesium Hydro… Oxethazaine
Esophagitis Radiation-induc…
The study stopped prematurely due to and administrative reasons, not based on grounds of safety.
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NCT00408473
Details
2022-02-07
Interventional
4-
Flecainide
Atrial Fibrilla…
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NCT04898309
Details
2022-02-04
Interventional
2/30 
Complement C1 I… Complement C1 I… Complement C1s
Angioedema Angioedemas, He… Hereditary Angi…
Company pipeline revision
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NCT03882918
Details
2022-02-04
Interventional
3125 
Gaboxadol
Angelman Syndro… Syndrome
Company decision
-