Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02501434
Details
2022-03-04
Interventional
2-
Calcium heparin Heparin
Aneurysm Hemorrhage Intracranial An… Neurobehavioral… Subarachnoid He… Thrombocytopeni… Vasospasm, Intr… Aneurysmal Suba… Heparin-induced…
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NCT01685606
Details
2022-03-04
Interventional
26 
Immunomodulatin…
Burkitt Lymphom… Leukemia Lymphoma Lymphoma, Large… Lymphoma, Mantl… Precursor Cell … Acute Myeloid L… Burkitts Lympho… Diffuse Large C… Mantle Cell Lym… T Cell Lymphoma…
Lack of accrual and low efficacy
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NCT01650350
Details
2022-03-04
Interventional
27 
Naltrexone
Carcinoma, Rena… Kidney Neoplasm… Melanoma Prostatic Neopl… Prostate Cancer Renal Cancer
Study stopped 10/24/13 secondary to lack of patients/slow enrollment
-
NCT01552590
Details
2022-03-04
Interventional
474 
Tolvaptan
Ascites Hyponatremia Hyponatremia an…
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-
NCT00198328
Details
2022-03-04
Interventional
384 
Bleomycin
Carcinoma Carcinoma, Squa… Head and Neck N… Head Neck Cance…
Enrollment was stopped based on the Data Monitoring Committee's recommendation.
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NCT00198315
Details
2022-03-04
Interventional
3130 
Bleomycin
Carcinoma Carcinoma, Squa… Head and Neck N… Head and Neck C…
Enrollment was stopped based on the Data Monitoring Committee's recommendation.
-
NCT03202147
Details
2022-03-03
Interventional
20 
Cromolyn Sodium
Cerebral Infarc… Cognitive Dysfu… Ischemia Ischemic Stroke Stroke Post-stroke Cog…
Study halted prematurely prior to initiation but potentially will resume in the future.
-
NCT02462538
Details
2022-03-03
Interventional
1/23 
Brentuximab Ved… Imatinib Mesyla…
Lymphoma Lymphoma, Large… ALK+ Anaplastic…
Due to slow recruitment, recruitment of new patients was stopped, FU was completed for enrolled patients
-
NCT04856475
Details
2022-03-02
Interventional
20 
Neratinib
Brain Neoplasms Breast Neoplasm… Neoplasm Metast… Brain Metastase… Breast Cancer
Termination of collaboration with PUMA
-
NCT04611139
Details
2022-03-02
Interventional
10 
Pembrolizumab
Carcinoma, Endo… Endometrial Neo… Endometrial Can… Ovarian Clear C… Ovarian Endomet… SCCOHT
Salarius discontinued support
-
NCT04459286
Details
2022-03-02
Interventional
257 
Atazanavir Sulf… Nitazoxanide Ritonavir
COVID-19 Covid-19
IDSMB recommendation
-
NCT04456023
Details
2022-03-02
Interventional
20 
Tisagenlecleuce…
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Non-H… Diffuse Large B…
This study was cancelled before enrolling any patients for business related reasons.
-
NCT04448834
Details
2022-03-02
Interventional
20 
Blinatumomab Vincristine
Leukemia Leukemia, Lymph… Precursor Cell … B-cell Acute Ly…
Study not moving forward
-
NCT03311269
Details
2022-03-02
Interventional
219 
Sodium Tetradec…
Venous Insuffic…
Study was terminated for administrative reasons
A total of 19 subjects were enrolled in the study. The study was terminated for administrative reasons; there were no safety or efficacy concerns. It was determined by the sponsor that the Phase 3 protocol, which is designed to closely mimic the Phase 2 protocol, would be adequate to collect safety and efficacy assessments with minor adjustments.
NCT03151304
Details
2022-03-02
Interventional
264 
Azacitidine
Myelodysplastic… Preleukemia Syndrome
Sponsor's decision as at the completion of the primary analysis, the data were considered mature
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NCT01455389
Details
2022-03-02
Interventional
1/225 
Dexamethasone Diphenhydramine Erlotinib Hydro… Promethazine
Lung Neoplasms Lung Cancer
Trial terminated by sponsor after decision to evaluate combination of quaratusugene ozeplasmid and osimertinib instead of further evaluating quaratusugene ozeplasmid and erlotinib.
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NCT00581477
Details
2022-03-02
Interventional
2/38 
Droxidopa
Autonomic Nervo… Hypotension Hypotension, Or… Nervous System … Orthostatic Int… Primary Dysauto… Dopamine Beta-H… Orthostatic Hyp…
1. enrollment slower than anticipated; 2. FDA approval of droxidopa so no longer need to treat patients on research basis; 3. personnel who were primarily responsible for the study are no longer at Vanderbilt.
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NCT03739138
2018-000845-37
Details
2022-02-28
Interventional
130 
Pembrolizumab
Neoplasms Advanced Solid …
Business Reasons
-
NCT03347123
2017-001743-12
Details
2022-02-28
Interventional
1/211 
Ipilimumab Nivolumab
Neoplasms Solid Tumors
A business decision made by Incyte after analysis of data from a sister study.
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NCT02323126
2014-003731-20
Details
2022-02-28
Interventional
264 
Nazartinib Nivolumab
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Sponsor decision due to low patient recruitment caused by the change in the treatment landscape of NSCLC.
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