Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03858049
Details
2024-03-12
Interventional
4172 
Dydrogesterone
Infertility
The trend in LPS treatment tends to increase the dosage of progesterone in FET-HRT, this study was designed 5 years ago.
-
NCT03646188
Details
2024-03-12
Interventional
113 
Doxorubicin Liposomal doxor…
Carcinoma Carcinoma, Basa… Basal Cell Carc…
Application of arrays was inconsistent.
-
NCT03151057
Details
2024-03-12
Interventional
116 
Idelalisib
Leukemia, Lymph… Lymphoma Lymphoma, Mantl… Lymphoma, Non-H… B Cell Chronic … B Cells-Tumors Follicular Lymp… Large B-Cell Di… Mantle Cell Lym…
Safety endpointreached
-
NCT02762266
Details
2024-03-12
Interventional
313 
Ethiodized Oil
Carcinoma Carcinoma, Hepa… Recurrence Child-Pugh Clas… Child-Pugh Clas… Recurrent Hepat…
Business decision - funding
This study did not enroll the planned number of participants and did not meet the protocol-prespecified threshold for statistical significance.
NCT01953926
2013-002872-42
Details
2024-03-12
Interventional
2582 
Fulvestrant Neratinib Paclitaxel Trastuzumab
Neoplasms Solid Tumors Ha…
The study was terminated to align with the sponsor's current development plans for neratinib. The decision was not based on any new efficacy or safety data for neratinib.
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NCT01886794
Details
2024-03-12
Interventional
410 
Estrogens
Pelvic Floor Di… Pelvic Organ Pr… Prolapse
Collaborator moved and not able to recreate full study team
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NCT01764451
Details
2024-03-12
Interventional
112 
Simvastatin
Congenital Abno… Hemangioma Hemangioma, Cav… Hemangioma, Cav… Cavernous Angio… Cerebral Cavern… Cerebral Cavern…
Research was completed before January 18, 2017, & does not meet the Applicable Clinical Trial requirement to register & report results per the guidance provided in "Clinical Trials Registration & Results Information Submission" dated 09/21/2016.
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NCT05946811
Details
2024-03-08
Interventional
30 
Macitentan
Embolism Pulmonary Embol…
Study was cancelled by funding agency before starting enrollment.
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NCT05720988
Details
2024-03-08
Interventional
10 
Azacitidine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Neoplasm, Resid… Acute Myeloid L…
trial was not opened
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NCT05689359
Details
2024-03-08
Interventional
20 
Hydroxychloroqu…
Breast Neoplasm… Peripheral Nerv… Breast Cancer Chemotherapy-in… Early-stage Bre… Gynecologic Can… Peripheral Neur…
Per Principal Investigator, it is not feasible to move forward with this trial.
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NCT05473234
Details
2024-03-08
Interventional
3307 
Amoxicillin Azithromycin
Malnutrition Severe Acute Ma…
Study was halted due to low follow-up rates and issues with data collection
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NCT05361993
Details
2024-03-08
Interventional
4-
Aripiprazole
Tic Disorders Tics
External factor: trial equipment problems
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NCT05056727
2021-001911-96
Details
2024-03-08
Interventional
3716 
Irbesartan Lisinopril Valsartan
Hyperkalemia Renal Insuffici… Renal Insuffici…
The study started enrollment in Sep 2021 and despite huge efforts the rate of patient enrollment continued to be below target such that the completion of the study within a reasonable timeframe was deemed very unlikely.
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NCT04905563
Details
2024-03-08
Interventional
430 
Acetaminophen Acetaminophen, … Hydrocodone Ibuprofen
Fractures, Bone Humeral Fractur… Supracondylar H…
Clinical evidence supporting the hypothesis of this study has been published
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NCT04870112
2020-006041-18
Details
2024-03-08
Interventional
118 
Carboplatin Durvalumab Etoposide
Carcinoma, Non-… Lung Neoplasms Small Cell Lung… Non-Small Cell … Small Cell Lung…
AstraZeneca has decided to stop further enrollment and the study was terminated when all patients in Part 1 completed their last study visit. No safety issues or clinical concerns however, have been identified for this study. Part 2 was not initiated
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NCT04478695
Details
2024-03-08
Interventional
11 
Pembrolizumab
Leukemia Leukemia, Myelo… Leukemia, Myelo… Relapsed or Ref…
Amgen Decision
This study was early terminated, leading to a small number of participants enrolled and analyzed.
NCT06085638
Details
2024-03-07
Interventional
1/20 
Azacitidine Venetoclax
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Chronic Myelomo…
Zero participants accrued
-
NCT05691478
NCT05683197
Details
2024-03-07
Interventional
2/3-
Cisplatin Doxorubicin Liposomal doxor… Methotrexate
Osteosarcoma High Grade Oste… Localized Osteo… Metastatic Oste… Secondary Osteo…
Scheduled Interim Monitoring
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NCT05034562
Details
2024-03-07
Interventional
20 
Edetic Acid Gallium 68 PSMA…
Carcinoma Prostatic Neopl… Metastatic Pros… Recurrent Prost… Stage IV Prosta… Stage IVA Prost… Stage IVB Prost…
Per PI no participants enrolled
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NCT04913675
Details
2024-03-07
Interventional
31065 
Sotrovimab
COVID-19 Covid19
The safety sub-study was discontinued early in the context of evolving variants with increased fold changes in the in vitro half maximal inhibitory concentration (IC50) and uncertainty in the clinical relevance of these changes
The pre-specified daily imputation resulted in overly high inflation in the estimated progression rates for missing data. To reduce this bias and to account for progression history, weekly imputation was used for final conclusions.